A look at economic developments around the globe

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New early warning system for seizures could lead to fewer false alarms

ScienceDaily (Apr. 3, 2012) ? Epilepsy affects 50 million people worldwide, but in a third of these cases, medication cannot keep seizures from occurring. One solution is to shoot a short pulse of electricity to the brain to stamp out the seizure just as it begins to erupt. But brain implants designed to do this have run into a stubborn problem: too many false alarms, triggering unneeded treatment. To solve this, Johns Hopkins biomedical engineers have devised new seizure detection software that, in early testing, significantly cuts the number of unneeded pulses of current that an epilepsy patient would receive.

Sridevi V. Sarma, an assistant professor of biomedical engineering, is leading this effort to improve anti-seizure technology that sends small amounts of current into the brain to control seizures.

"These devices use algorithms -- a series of mathematical steps --to figure out when to administer the treatment," Sarma said. "They're very good at detecting when a seizure is about to happen, but they also produce lots of false positives, sometimes hundreds in one day. If you introduce electric current to the brain too often, we don't know what the health impacts might be. Also, too many false alarms can shorten the life of the battery that powers the device, which must be replaced surgically."

Her new software was tested on real-time brain activity recordings collected from four patients with drug-resistant epilepsy who experienced seizures while being monitored. In a study published recently in the journal Epilepsy & Behavior, Sarma's team reported that its system yielded superior results, including flawless detection of actual seizures and up to 80 percent fewer alarms when a seizure was not occurring. Although the testing was not conducted on patients in a clinical setting, the results were promising.

"We're making great progress in developing software that is sensitive enough to detect imminent seizures without setting off a large number of false alarms," Sarma said. Further fine-tuning is under way, using brain recordings from more than 100 epilepsy patients at The Johns Hopkins Hospital, where several epilepsy physicians have joined in the research. Sarma said that within two to four years she hopes to see her system incorporated into a brain implant that can be tested on people with drug-resistant epilepsy.

"There is growing interest in applying responsive, or closed-loop, therapy for the treatment of epileptic seizures," said Gregory K. Bergey, M.D., professor of neurology and director of the Johns Hopkins Epilepsy Center. "Devices to do this have been tested in humans, but for this therapy to be useful for the patient with epilepsy requires early detection of abnormal brain activity that is destined to become a seizure. Detection has to be within seconds of seizure onset, before the seizure spreads to cause disabling symptoms such as alteration of consciousness."

He added, "Developing detection methods that can both provide this early detection and yet not be triggered by brain activity that will not become a clinical seizure has been a real challenge. Dr. Sarma's group appreciates how important this is. The application of their detection algorithms has produced promising preliminary results that warrant further study of more seizures in more patients."

In trying to solve the seizure false-alarm problem, Sarma drew on her training in electrical engineering, particularly a discipline called control theory. "We decided to start with the origin of the signal in the brain," she said.

Sarma's team compared electrical data from the brains of epilepsy patients before, during and after seizures. The researchers looked at how this activity changed over time, particularly when a seizure began. "We wanted to figure out when would be the optimal time to step in with treatment to stop the seizure," she said. The team members "trained" their system to look for that moment without setting off false alarms.

Ideally, Sarma would someday like to see her software embedded in a microchip that would continually check electrical activity in the brain and launch electrical stimulation whenever a seizure is just beginning to form. The device would operate as a closed loop system, resembling a thermostat that keeps a room's temperature at a constant, comfortable level.

Sarma's interest in brain disorders developed relatively late in her education. She earned a bachelor's degree from Cornell University in electrical engineering, then master's and doctoral degrees at MIT, both in electrical engineering and computer science. During her doctoral studies, however, she pursued a minor in neuroscience. For a class, she conducted a case study of her aunt, who had developed Parkinson's disease at age 29 and had trouble managing it with medication. Watching her aunt's condition was an emotionally draining experience, Sarma said, and she wondered if anything in her own training could help. "I really wanted to understand the neurobiological circuitry of this disease," she said.

That led Sarma to learn more about deep brain stimulation, the use of electric pulses to treat brain disorders such as Parkinson's and epilepsy. She completed a postdoctoral fellowship in MIT's Brain and Cognitive Sciences Department and became a neuroscience research associate affiliated with Massachusetts General Hospital and Harvard Medical School.

In 2009, Sarma joined the faculty of Johns Hopkins' Department of Biomedical Engineering, which is shared by the School of Medicine and the Whiting School of Engineering. She also is a core faculty member in the university's Institute for Computational Medicine. In 2011, Sarma was named a recipient of a Faculty Early Career Development Award from the National Science Foundation.

Her team's new system for seizure detection with reduced false alarms is protected by a patent obtained through the Johns Hopkins Technology Transfer office.

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The above story is reprinted from materials provided by Johns Hopkins, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Sabato Santaniello, Samuel P. Burns, Alexandra J. Golby, Jedediah M. Singer, William S. Anderson, Sridevi V. Sarma. Quickest detection of drug-resistant seizures: An optimal control approach. Epilepsy & Behavior, 2011; 22: S49 DOI: 10.1016/j.yebeh.2011.08.041

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Plan cuts California high-speed rail plan cost

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Non-Toxic Kids: The Breast Cancer Fund Responds to the FDA ...

Late Friday afternoon, on the eve of its legal deadline and at probably the best possible time to avoid media scrutiny, the U.S. Food and Drug Administration announced it has rejected the 2008 Natural Resources Defense Council petition requesting that the toxic chemical bisphenol A, or BPA, be declared unsafe and banned from food packaging.

The FDA said it "has determined, as a matter of science and regulatory policy, that the best course of action at this time is to continue our review and study of emerging data on BPA," and that "this announcement is not a final safety determination and the FDA continues to support research examining the safety of BPA."

This weak response is deeply disappointing and calls into question the FDA's ability to take decisive action to protect public health.

The body of evidence against BPA has been mounting over the years we've been calling on the FDA to make a definitive determination on BPA's safety. Most of us are exposed to BPA every day. In fact, the CDC found BPA in 93 percent of all Americans tested, and the National Institutes of Health point to food packaging, including food cans, which are lined with BPA, as a major route of exposure. BPA has been found in blood and urine of pregnant women, in the umbilical cord blood of newborns and in breast milk soon after women gave birth. Nearly 200 lab studies show that exposures to even low doses of BPA, particularly during pregnancy and early infancy, are associated with a wide range of adverse health effects later in life, including breast cancer. Studies show that BPA exposure can make non-cancerous breast cells grow and survive like cancer cells, and can actually make the cells less responsive to the cancer-inhibiting effects of tamoxifen, a drug used in the treatment of breast cancer.

Yet the FDA is saying it wants even more evidence of harm before acting. If BPA were a potential pharmaceutical drug, it is highly doubtful that, given the adverse effects already seen in animal models, it would ever be allowed into clinical trials in humans. Indeed, we are all currently part of an uncontrolled human BPA experiment.

The rejection of the NRDC petition is far from the last decision the FDA will have to make on BPA, and far from the last word from the public and policy makers. Two weeks ago, Rep. Ed Markey, D-Mass., formally petitioned the FDA to ban the use of BPA in food packaging. Markey has also introduced legislation, the Ban Poisonous Additives Act, that would instruct the FDA to ban BPA from all food packaging. Even the American Chemistry Council, which represents companies that manufacture BPA and has spent millions lobbying aggressively on behalf of BPA, submitted a petition to the FDA in December requesting that the agency ban the hormonally active chemical from baby bottles.

The FDA's inaction is in stark contrast to consumer, business and legislative action. Last month, the Breast Cancer Fund's Cans Not Cancer campaign publicized the fact that Campbell Soup Company will phase out the use of BPA in its can linings. Baby bottle and sports water bottle manufacturers abandoned BPA over the last few years. At the public policy level, 11 states have banned BPA from baby bottles and sippy cups, and three of those states have also banned it from infant formula and baby food.

Scientists, consumers, retailers, manufacturers and the states are sending clear signals that BPA doesn't belong in our food packaging and that investment in safe alternatives is an investment in the health of the American public. Now the FDA needs to catch up. Inaction is not acceptable. The FDA needs to take decisive, urgent action to ensure that all of us - regardless of where we live or where we shop - are protected from this toxic chemical.

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Build Muscle | Make This Your Fittest Summer Ever With The MostFit ...

LOS ANGELES , CA?(Marketwire -04/02/12)- When celebrities have to get in shape, they spend hours at it, often with the help of a certified ? and expensive ? personal trainer . For the rest of us, we?re lucky we can squeeze any exercise into our schedules, what with the daily demands of work and family life. That?s where the MostFit Suspension Strap comes in, offering you ?grab-and-go exercise? and at little cost. Created by fitness expert Andrew Gavigan , the MostFit Suspension Strap is a safe, affordable and most importantly, portable way to get your workout on ? at home, at the office, or on the road ? and without the need for an expensive gym membership, personal trainer, or any other fitness equipment whatsoever. Offered at an MSRP of just $29.99, the MostFit Suspension Strap is available for purchase at www.most-fit.com .

As MostFit Suspension Strap creator Andrew Gavigan repeatedly tells his clients, ?Be the most fit you can be. Anytime. Anywhere.? Body weight training with the MostFit Suspension Strap will strengthen all of your major muscles, while improving balance and core strength, helping you to build lean muscle, boost your metabolism, increase endurance, and tighten your core. Its simple yet effective design makes it easy to use? anytime, anywhere. Lightweight and compact, the MostFit Suspension Strap conveniently anchors to doors, making it readily available for home or office use, or on the road in your hotel room. Extremely durable, the MostFit Suspension Strap can also be used outdoors, looped around a tree trunk, swing set, and just about anything you can get your hands on. Check it out:

You?re probably wondering what makes the MostFit Suspension Strap unique in a market that is saturated with thousands of fitness products. At just $29.99 per unit, the MostFit Suspension Strap costs significantly less than the leading suspension training products on the market. An all-in-one solution, the MostFit Suspension Strap also offers easier portability and easier set-up; there are no extra parts or adjustable clips to get in the way of your workout, and the anchor is attached. Additionally, the MostFit Suspension Strap weighs significantly less than some of the leading straps on the market, and contains no metal parts, so it can easily be brought in your carry-on luggage for air travel.

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A single, contained unit, all adjustments are made using your own body! The angle of the body changes the resistance for every inch you step forward or back ? offering the ability to increase or decrease your challenge, intensity, and the impact on your joints. If push-ups come easy to you, you can easily put your feet in the straps and do a multi-joint, core-challenging combo exercise. If you do not yet have the upper body and core strength to do a traditional or horizontal push-up, you can do a standing incline push-up, decreasing the pressure on your joints. As you get stronger, you can change your angle to challenge yourself more.

With daily life becoming increasingly hectic, the fitness industry has become a convenience business. Since workout frequency is crucial to reaping the rewards of regular exercise, workouts have got to be convenient. This means that they need to be as close as possible to where individuals work or live, or better yet, in their glove compartments, brief cases, carry-ons, backpacks, and purses so they can work out anytime, anywhere.

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ABOUT ANDREW GAVIGAN
Certified fitness trainer and yoga instructor, Andrew Gavigan, created The MostFit Suspension Strap. A self-proclaimed ?Mobile Fitness Expert,? Gavigan spent several years traveling with a rock band, developing an expertise in ?Fitness on the Road.? The MostFit Suspension Strap was born out of that, and Gavigan?s belief that people who do not have a lot of free time or resources can still achieve a higher level of health and fitness. A certified fitness trainer by the National Federation of Professional Trainers, Gavigan holds additional certifications in pre- and post-natal exercise, post rehab exercise, assisted/PNF stretch, and yoga. In addition to his personal clientele, Gavigan teaches group exercise at some of Los Angeles?s hottest gyms, including Pulse Fitness, which was voted the ?Best Fitness Studio in Los Angeles? by Fox LA. He is also a part of cutting-edge executive wellness programs at companies like Red Bull N.A., which are leading the way to a healthier and more productive workforce.

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Skulls; sharks and polka dots in Damien Hirst show

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Nokia 7110 review

To say that Nokia's 7110 is an easy phone to review is something of an understatement. This is the first handset to ship running the company's Series 40 OS, but it also packs a dual-band GSM modem and a WAP browser. All of that is shoved into a handset no larger than your average candy bar. Of course, for all of its technical achievement, you're likely to be too busy focusing on its similarity to the customized Nokia 8110 used in The Matrix. The spring-loaded phone in the movie was merely the fever dream of art director Owen Paterson, albeit one that's now brought to life. But is its famous exterior a boon or a burden and does all that style detract from the substance? Pop a red pill and follow us down the rabbit hole for a closer look.

Gallery: Nokia 7110 Review

Continue reading Nokia 7110 review

Nokia 7110 review originally appeared on Engadget on Sun, 01 Apr 2012 10:00:00 EDT. Please see our terms for use of feeds.

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